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‘Nuzzeld’ headlines for 20March18

JUST ‘NUZZELED’ ▶ Fortune – Mar 20, 2018, 3:57 PM – LAGUNA NIGUEL, Calif.—The cost to develop and gain FDA approval for a new drug today is more than $2.5 billion, according to the Tufts Center for the Study of Drug Development. Driving much of that cost are human clinical trials. They're… SEE ▶ NUZZEL

According to a press release, the treatment combats the disease by using chemotherapy to suppress their immune system, then "resetting" it with an injection of their own stem cells taken from the blood and bone marrow. The trial involved over 100 patients with relapsing-remitting MS, in whom the disease ...

Dieter Egli was just about to start graduate school in 1998 when researchers first worked out how to derive human embryonic stem cells. In the two decades since, the prolific cells have been a fixture of his career. The biologist, now at Columbia University in New York City, has used them to explore 

March 20, 2018 -- Stem cell therapy restored some vision to two patients with a common cause of blindness called age-related macular degeneration, U.K. doctors say. Stem cells from a human embryo were converted into a patch of a specific type of eye cell and grown in the lab. The patch 


Marketwired – Mar 1, 2018 – NESS-ZIONA, ISRAEL--(Marketwired - March 01, 2018) - VAXIL BIO LTD. (TSX VENTURE: VXL), an innovative Israeli cancer research company focused on immunotherapy, is pleased to announce that it has successfully obtained a U.S. Patent for its Signal…
PDF ▶ ▶ see embedded content below

VAXIL, seems to be an actually mass-produced vaccine (like the polio vaccine), but CART-T is an individually bio-engineered therapy based on a patient's own genetics. More on CART-T  ▶ and more on VAXIL @

▶ My MCL DX came in April 2006 (age 57 and I will be 70 in June), blastoid type, with a following almost 16 months of various chemo regimens starting with *R-CHOP, then others. Had an unrelated German donor SCT in Aug. 2007 and two years of full remission. But a single-tumor relapse in Oct. 2009 was treated successfully with targeted radiation (Tomotherapy) and I have been in full remission since that time. Only maintenance therapy now is periodic IVIGs. Going on a 12-year survival mark, I guess I have reached the long-term category? The bulk of my treatment was at City of Hope, Duarte, CA (east of Los Angeles)
▶ My single-tumor relapse in 2009 was explained by my oncologist as common with MCL. In layman's terms, he explained that rare tumors have a way of hiding from the effects of chemo and treatment. That reason may be the chief cause of how elusive a cure is for this disease.
▶ *The “R” in R-CHOP stands for “Rituximab,” used widely around the world and proven effective as a cancer-fighting and remission maintenance drug. However, chemo patients should consult their oncologist about the major known side-effect. Now that I am approaching ten years of remission post an allogeneic SCT, the only maintenance therapy I require is frequent (every 2-3 months) immunoglobulin infusions (IviGs). The purported cause: lingering effects of Rituximab? Thank you, I'll take the remission! VIDEO ▶

“When you change the way you look at things, the things you look at change”
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Secondary Immunodeficiency Disease (post allogeneic SCT for MCL)   They say that necessity is the mother of invention, archaic, yes, but applied often to the human experience.

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