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Thursday, August 16, 2007

Q&A: Stem Cells

Photo: Stem cells shown through an electron microscope

One of my readers of MyJournal responded with a question as to why my upcoming stem cell transplant (SCT) did not involve surgery when he asked: "Don't stem cells come from the brain stem?"

Actually, stem cells are in the brain stem and found throughout the body in all tissues and organs. These are the base cells from which all other cells are derived. That's why stem cell research holds such promise for the treatment and cure of so many diseases like cancer and diabetes and major medical disabilities like paralysis.

Scientists around the world are working on techniques to refine stem cell therapy. However, their use is mired in controversy.


What are stem cells?

Most adult cells in the body have a particular purpose which cannot be changed.

For instance, a liver cell is developed to perform specific functions, and cannot be transformed to suddenly take on the role of a heart cell.

Stem cells are different. They are still at an early stage of development, and retain the potential to turn into many different types of cells.

Why are they so useful?

When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialised function.

Scientists believe it should be possible to harness this ability to turn stem cells into a super "repair kit" for the body.

Theoretically, it should be possible to use stem cells to generate healthy tissue to replace that either damaged by trauma, or compromised by disease.

Among the conditions which scientists believe may eventually be treated by stem cell therapy are Parkinson's disease, Alzheimer's disease, heart disease, stroke, arthritis, diabetes, burns and spinal cord damage.

Stem cells may also provide a useful way to test the effects of experimental drugs.

It is also hoped that studying stem cells will provide vital clues about how the tissues of the body develop, and how disease takes hold.

Are there different types of stem cell?

Yes. Scientists believe the most useful stem cells come from the tissue of embryos.

This is because they are pluripotent - they have the ability to become virtually any type of cell within the body.

Stem cells are also found within adult organs. They have not taken on a final role, and have the potential to become any of the major specialised cell types within that organ.

Their role is to maintain the organ in a healthy state by repairing any damage it suffers.
It is thought their potential to become other types of cell is more limited than that of embryonic stem cells. But there is evidence that they are still relatively "plastic".

Can they be easily grown in the lab?

Large numbers of embryonic stem cells can be relatively easily grown in culture.

However, adult stem cells are rare in mature tissues and science is still working on ways to grow them in the lab in sufficient numbers.

This is an important distinction, as large numbers of cells are needed for stem cell replacement therapies.

Adult stem cells do have one big advantage. It should theoretically be possible to take stem cells from a patient, grow them in culture, and then transplant them back into the patient without fear that they would be attacked by the body's immune system.

Is the use of stem cells controversial?

Very. Campaigners are vehemently opposed to the use embryonic stem cells.

These cells are typically taken from lab-created embryos that are just four or five days old, and are little more than a microscopic ball of cells.

However, opponents argue that all embryos, whether created in the lab or not, have the potential to go on to become a fully fledged human, and as such it is morally wrong to experiment on them.

They strongly advocate the use of stem cells from adult tissue.

Are there safety concerns?

Yes. Some researchers fear that it is possible that stem cell therapy could unwittingly pass viruses and other disease causing agents to people who receive cell transplants.

There is particular concern that stem cells are currently cultivated using nutrients taken from animal sources, and that these could harbour diseases which could be passed on to humans.
Some research has also raised the possibility that stem cells may turn cancerous.

Note: While stem cells are found throughout the body, these are harvested from the blood stream or bone marrow for stem cell transplants for cancer patients. The process is much like a blood transfusion and requires no surgery, except for the installation of a special catheter through which the stem cells from the donor are delivered to the patient.


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